Optimal cache setup for a big membership site

We are about the roll out huntingplanit.com. It's been quite a project with lots of new great stuff including EasyBlog, EasyDiscuss and EasySocial. All fantastic.. We've moved to dedicated hosting now that the heavy lifting is done relative to configuration and design. Responsie time much improved. My practice is to disable cache during the build. But given this is already a big site which will become even more graphic-intensive, do you guys have any thoughts on whether the livesite should use caching? My partner thinks yes but I wanted to check with you.
Many thanks as always.
-Jim G.