How can I differentiate module assignments between different layouts/views?

Hey guys,

My idea: I want to create sth. like a magazine portal on the blog's frontpage, with a lot of modules over the whole width – and when someone clicks on an article, he sees totally different (= less) modules, pref. only sidebar modules.

How can I do that?

I want to have one module combination for every blog post, and one on the blog frontpage. And maybe some more for the specific layouts (for example the Archive Layout / View etc.).

Thanks
Colin